(-)-Equol | B3081

S-equol is a metabolite of soy isoflavonoid phytoestrogen daidzein, produced by human intestinal bacteria. S-equol has a high affinity for estrogen receptor beta (ERβ) than estrogen receptor (ERα) with Ki values of 0.73 and 6.4 nM respectively. It inhibits the growth of LnCaP, DU145 and PC3 human prostate cancer cell lines. It has significant anti-prostate cancer activities in vitro and in vivo. The anticancer effects are associated with the activation of FOXO3a via an Akt-specific pathway and inhibitory effects on MDM2 expression.

S-equol is a metabolite of soy isoflavonoid phytoestrogen daidzein, produced by human intestinal bacteria. S-equol has a high affinity for estrogen receptor beta (ERβ) than estrogen receptor (ERα) with Ki values of 0.73 and 6.4 nM respectively. It inhibits the growth of LnCaP, DU145 and PC3 human prostate cancer cell lines. It has significant anti-prostate cancer activities in vitro and in vivo. The anticancer effects are associated with the activation of FOXO3a via an Akt-specific pathway and inhibitory effects on MDM2 expression.

B3081 | (-)-Equol DataSheet

Alternate Name/Synonyms: (3S)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol; (S)-Equol; 4',7-Isoflavandiol; 4',7-Dihydroxyisoflavan; (S)-3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol

Appearance: White Solid

Formulation:

CAS Number: 531-95-3

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₅H₁₄O₃

Molecular Weight: 242.27

Cell-Permeable?: TRUE

Purity: ≥ 98%

Solubilities: ~15 mg/ml in DMSO, DMF or ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A high affinity agonist for ERβ

MDL Number: MFCD00200962

PubChem CID: 91469

SMILES: C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O

InChi: InChI=1S/C15H14O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-6,8,12,16-17H,7,9H2/t12-/m1/s1

InChi Key: ADFCQWZHKCXPAJ-GFCCVEGCSA-N