3-Deazaneplanocin A | 2060

A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.

3-Deazaneplanocin is a lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.

2060 | 3-Deazaneplanocin A DataSheet

Alternate Name/Synonyms: DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol

Appearance: Off-white solid

Formulation: N/A

CAS Number: 102052-95-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₂H₁₄N₄O₃

Molecular Weight: 262.26

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (20 mg/ml) or EtOH (1 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A lysine methyltransferase EZH2 (KMT63) inhibitor

MDL Number: MFCD12545899

PubChem CID: 73087

SMILES: C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N

InChi: InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11 (8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1

InChi Key: OMKHWTRUYNAGFG-IEBDPFPHSA-N