(2R,6R)-Hydroxynorketamine | B3291

(2R,6R)-Hydroxynorketamine hydrochloride is a ketamine metabolite that enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). Acts as an antidepressant.

(2R,6R)-Hydroxynorketamine hydrochloride is a ketamine metabolite that enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in PC-12 cells (IC50 = 0.68 nM). Acts as an antidepressant.

B3291 | (2R,6R)-Hydroxynorketamine DataSheet

Alternate Name/Synonyms: (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride

Appearance: White solid

Formulation:

CAS Number: 1430202-69-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₄ClNO₂.HCl

Molecular Weight: 276.16

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~10 mg/ml Water >25 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A ketamine metabolite and an ant-depressant

MDL Number:

PubChem CID: 121513910

SMILES: C1CC(C(=O)C(C1)(C2=CC=CC=C2Cl)N)O.Cl

InChi: InChI=1S/C12H14ClNO2.ClH/c13-9-5-2-1-4-8(9)12(14)7-3-6-10(15)11(12)16;/h1-2,4-5,10,15H,3,6-7,14H2;1H/t10-,12-;/m1./s1

InChi Key: ZQJVHBJDLMIKJK-MHDYBILJSA-N