27-Hydroxycholesterol | B2988

27-Hydroxycholesterol is a hydroxylation product of cholesterol which is produced by the activity of the enzyme sterol 27-hydroxylase. It activates LXRα and LXRβ in vitro with EC₅₀ values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis. The levels of 27-hydroxycholesterol are elevated in patients with Alzheimer's disease and mild cognitive impairment.

27-Hydroxycholesterol is a hydroxylation product of cholesterol which is produced by the activity of the enzyme sterol 27-hydroxylase. It activates LXRα and LXRβ in vitro with EC₅₀ values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis. The levels of 27-hydroxycholesterol are elevated in patients with Alzheimer's disease and mild cognitive impairment.

B2988 | 27-Hydroxycholesterol DataSheet

Alternate Name/Synonyms: (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (25R)-26-hydroxy Cholesterol; (3β,25R)-Cholest-5-ene-3,26-diol; 25(R)-27-hydroxy Cholesterol

Appearance: White Solid

Formulation:

CAS Number: 20380-11-4

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₂₇H₄₆O₂

Molecular Weight: 402.65

Cell-Permeable?: True

Purity: 0.98

Solubilities: ~20 mg/ml in Ethanol, ~2 mg/ml in DMF, ~0.1 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A hydroxylation product of cholesterol and LXRα and LXRβ activator

MDL Number: MFCD00272990

PubChem CID: 123976

SMILES: CC(CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C)CO

InChi: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

InChi Key: FYHRJWMENCALJY-YSQMORBQSA-N