(R,S)-Rolipram | 2010

Cell-permeable. A Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC₅₀ = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes.

(R,S)-Rolipram is a selective inhibitor of cAMP phosphodiesterase (PDE4) (IC₅₀ = 2.0 μM). Discriminates between two conformational states of PDE4 isoenzymes.

2010 | (R,S)-Rolipram DataSheet

Alternate Name/Synonyms: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

Appearance: White solid

Formulation: N/A

CAS Number: 61413-54-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₂₁NO₃

Molecular Weight: 275.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 75 mM) or EtOH (~ 75 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective PDE4 inhibitor

MDL Number: MFCD00270906

PubChem CID: 5092

SMILES: COC1=C(C=C(C=C1)C2CC(=O)NC2)OC3CCCC3

InChi: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)

InChi Key: HJORMJIFDVBMOB-UHFFFAOYSA-N