(S)-H-1152 dihydrochloride | B1106

H-1152 dihydrochloride is a potent, cell permeable, specific, ATP-competitive inhibitor of Rho-kinase (ROCK) (Ki = 1.6 nM). H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 μM, respectively).

H-1152 dihydrochloride is a potent, cell permeable, specific, ATP-competitive inhibitor of Rho-kinase (ROCK) (Ki = 1.6 nM). H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 μM, respectively).

B1106 | (S)-H-1152 dihydrochloride DataSheet

Alternate Name/Synonyms: (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

Appearance: White Solid

Formulation: N/A

CAS Number: 451462-58-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: Yes

Molecular Formula: C₁₆H₂₁N₃O₂S.2HCl

Molecular Weight: 392.34

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>15 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent, specific ATP-competitive rho-kinase (ROCK) inhibitor

MDL Number: MFCD06411451

PubChem CID: 11560225

SMILES: CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl

InChi: InChI=1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1

InChi Key: BFOPDSJOLUQULZ-GXKRWWSZSA-N