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GDF-2 belongs to the TGF- cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-2...

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily...

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These...

6780 | BMPR2 Antibody (NT) DataSheet

BMS-1001 is a potent inhibitor of the interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) (IC50 = 2.25 nM). BMS-1001 is capable of alleviating...

BMS-191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Acts as a neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a...

BMS-299897 is a potent, brain-permeant γ-secretase inhibitor (IC₅₀ = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC₅₀ values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain,...

BMS-3 is a potent and specific inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC₅₀s = 5 and 6 nM, respectively). LIMK1 is responsible for the inactivation of cofilin (ADF family protein),...

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL) (IC₅₀ = 0.13 µM for human recombinant ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC₅₀ of 8 μM, and lowers plasma...

BMS-345541 is a highly selective inhibitor of IKK-1 and IKK-2 with IC₅₀ value of 4 μM and 0.3 μM, respectively. It binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent...

BMS-536924 is a dual inhibitor of insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IC₅₀s = 100 and 73 nM, respectively). Inhibits receptor autophosphorylation and downstream...

BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor.BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor.B1704 |...

An orally bioavailable pan-HER tyrosine kinase inhibitor with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby...

BMS-626529 is a potent attachment inhibitor of HIV-1 gp120 with IC₅₀ values of 2.26 nM, 0.34 nM and 1.3 nM for HIV-1 subtype A, B, and C envelope, respectively.BMS-626529 is a potent attachment...

BMS-663068 (Fostemsavir) is a potent HIV-1 attachment inhibitor. Fostemsavir is a prodrug of the small-molecule inhibitor BMS-626529 (Cat. No. B1557) which inhibits human immunodeficiency virus type...

BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectivelyBMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with...

BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor (IGF-1R/IR) family kinases (Ki,

A potent, selective and ATP-competitive Met kinase superfamily inhibitor (IC₅₀ = 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM for c-Met, Axl, RON, and Tyro-3, respectively). it was >40-fold selective for Met...

BMS-779788 is a LXR partial agonist with IC₅₀ values of 68 nM for LXRα and 14 nM for LXRβ. BMS-779788 induces LXR target genes in blood in vivo with an EC₅₀ = 610 nM, a value similar to its in vitro...

BMS-794833 is a potent, ATP-competitive inhibitor of Met and VEGFR2 with IC₅₀ of 1.7 nM and 15 nM, respectively. It also inhibits Ron, Axl, and Flt-3 with IC₅₀ values

BMS-813160 is a potent antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). BMS-813160 specifically binds and prevents the...

BMS-833923 is a potent inhibitor of Smo (Smoothened) with potential antineoplastic activity. It blocks binding of BODIPY cyclopamine (IC₅₀ = 21 nM) and inhibits Gli activation in cell lines that...

BMS-863233 is a potent and selective CDC7 (cell division cycle 7 homolog) inhibitor. BMS-863233 binds to and inhibits the activity of CDC7, resulting in the inhibition of DNA replication and mitosis,...

BMS-911543 is a potent and selective JAK2 inhib itor. It displays potent anti-proliferative and pharmacodynamic effects in cell lines dependent upon JAK2 signaling, and has little activity in cell...

BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor (IC50 = 2.8 nM). It is more potent against BTK than other kinases, including the other Tec family kinases (TEC, BMX, ITK,...

BMS-986020 is a potent G protein-coupled lysophosphatidic acid receptor 1 (LPA1) antagonist. LPA receptor is involved in binding of the signaling molecule lysophosphatidic acid, which in turn is...

BMS-986142 is a potent, selective, and reversible BTK (Bruton’s tyrosine kinase) inhibitor (BTK IC₅₀ = 0.5nM; human WB IC₅₀ = 90 nM). BMS-986142 displays robust efficacy in murine models of...

BMS-986158 is a potent bromodomain (BRD) and extra-terminal domain (BET) family inhibitor. BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the...

BMS-986205 is a potent and selective IDO1 (indoleamine 2,3-dioxygenase 1) inhibitor. Does not have much effect on IDO2 (indoleamine 2,3-dioxygenase 2) or TDO (Tryptophan 2,3-dioxygenase).BMS-986205...

BMS-P5 is a potent and selective inhibitor of peptidylarginine deiminase 4 (PAD4). It significantly reduces Multiple myeloma-cells induced citrullination of histone H3 and formation of neutrophil...

The BMX gene encodes a novel non receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells (1). Bmx cDNA comprises a long open reading frame of 675...

BMX-IN-1 is a highly selective and potent irreversible inhibitor of BMX kinase.BMX-IN-1 is a highly selective and potent irreversible inhibitor of BMX kinase.B1330 | BMX-IN-1 DataSheetAlternate...

BN-82002 is a cell-permeable CDC25 Phosphatase Inhibitor. BN-82002 is a potent, cell-permeable, selective, and irreversible inhibitor of CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6...

BNC-105 | B3381Description: BNC-105 is a tubulin polymerization inhibitor and vascular disrupting agent (VDA) with potent antiproliferative and tumor vascular disrupting properties.Alternate...

3205 | Bnip3L/Nix Antibody DataSheet

6962 | BNP Antibody DataSheet

Natriuretic Peptide Precursor B acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It...

Bobcat339 is a potent cytosine-based TET (ten-eleven translocation methylcytosine dioxygenase) enzyme inhibitor with IC50 of 33 µM (TET1) and 73 µM (TET2). Bobcat339 does not inhibit the DNA...

A synthetic peptide that irreversibly inhibits activity of caspase family proteases and blocks apoptosis. The inhibitor is designed as a methyl ester to facilitate cell permeability. The product can...

Boceprevir is a protease inhibitor that binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication,...

BODIPY-acetylene is a useful reagent to prepare BODIPY-linked conjugates of lipids, fatty acids, triglycerides, etc. employing click chemistry.BODIPY-acetylene is a useful reagent to prepare...

A fluorescent Cyclopamine (Cat. No. 1578-5) derivative that retains potency in Shh signaling inhibition (IC₅₀ = 150 nM).BODIPY-Cyclopamine is a fluorescent Cyclopamine (Cat. No. 1578-5) derivative...

Bohemine is a potent and selective, cell-permeable, cyclin-dependent kinase (CDK) inhibitor IC₅₀ = 1 µM). Arrests cell cycle in the G/S boundary and activates mature bovine oocytes. Bohemine is...

3043 | Bok Antibody DataSheet

A potent inhibitory ligand of the mitochondrial adenine nucleotide translocase (ANT). Inhibits mitochondrial permeability transition pore opening. Also blocks NMDA receptor-mediated apoptosis of...

3888 | Boris Antibody DataSheet

3888BP | Boris Blocking Peptide DataSheetAntibody Target: Boris Accession #: NP_114012Gene ID: 83726Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate...

Boromycin is a boron-containing macrolide antibiotic that displays antibacterial, and antiprotozoal properties. Boromycin (3.4 nM) reverses bleomycin-induced cell cycle arrest at the G2 phase in...

A macrolide antibiotic isolated from Streptomyces sp. An antiangiogenic (IC₅₀ = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed...

Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM). Inhibits ET-1 induced contraction of isolated rat aorta and sarafotoxin S6C-induced contraction of...

Bostrycin is a tetrahydroanthraquinone isolated from Bostrychonema aloestre. It induces mitochondria-mediated apoptosis in the yeast saccharomyces cerevisiae, inhibits proliferation of human lung...

Bosutinib (SKI-606) is a novel tyrosine kinase inhibitor. Bosutinib can overcome not only Bcr-Abl-dependent mechanisms of resistance, but also those that are Bcr-Abl-independent. It is used to treat...

Proteolytic cleavage of the coagulation factor X produces the activated form, Factor Xa. Factor Xa participates in the prothrombinase complex of the coagulation cascade to induce blood clotting. This...

Proteolytic cleavage of the coagulation factor X produces the activated form, Factor Xa. Factor Xa participates in the prothrombinase complex of the coagulation cascade to induce blood clotting. This...

Bovine Serum Albumin – Fraction V, 30% Solution | 7914

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

’s BSA is prepared by utilizing the Cohn Cold Ethanol Precipitation Process. This process is optimal for preserving the nutrient factors critical to the applications of cell culture, leptospira and...

This BSA was purified by a proprietary heat shock process to inactivate proteases. The product is further processed to remove lipids and other plasma proteins by a non-solvent procedure. BSA makes up...

This BSA was purified by a proprietary heat shock process. BSA makes up approximately 60% of all proteins in animal serum. It is commonly used in cell culture protocols, particularly when protein...

This BSA was purified by a proprietary heat shock process to inactivate proteases. Additional treatments include charcoal treatment, deionization and dialysis steps. BSA makes up approximately 60% of...

This BSA was purified by a proprietary heat shock process. BSA makes up approximately 60% of all proteins in animal serum. It is commonly used in cell culture protocols, particularly when protein...

This BSA was purified by a proprietary heat shock process. BSA makes up approximately 60% of all proteins in animal serum. It is commonly used in cell culture protocols, particularly when protein...

This BSA was purified by a proprietary heat shock process. BSA makes up approximately 60% of all proteins in animal serum. It is commonly used in cell culture protocols, particularly when protein...

This BSA was purified by a proprietary heat shock process. BSA makes up approximately 60% of all proteins in animal serum. It is commonly used in cell culture protocols, particularly when protein...

This BSA was purified by a proprietary heat shock process. BSA makes up approximately 60% of all proteins in animal serum. It is commonly used in cell culture protocols, particularly when protein...

BPTES is an allosteric glutaminase (GLS1) inhibitor (IC₅₀ = 3.3 μM). Displays selectivity for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro...

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such...

An allosteric P2Y1 antagonist. Prevents inhibition of spontaneous contraction of rat and mouse colon induced by electrical field stimulation, nicotine and P2Y agonists. Acts as n antithrombotic agent...

A bisperoxovanadium compound that acts as a potent protein phosphotyrosine phosphatase (PTP) inhibitor as well as an insulin receptor kinase (IRK) activator. Also an excellent insulin mimetic in...

A bisperoxovanadium compound that acts as a potent protein phosphotyrosine phosphatase (PTP) inhibitor as well as an insulin receptor kinase (IRK) activator. Also a potent PTEN inhibitor (IC₅₀ = 31...

BQ-123 sodium is a potent and selective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). It also inhibits ET-1 receptor binding and blocks...

BQ-610 is a highly potent and selective ETAR (ETA receptor) antagonist (IC₅₀ = 20 nM) that ttenuates ET-induced reduction in cardiac output. It also inhibits ET-1- and ET-3-induced activation of...

BQ-788 is a potent and selective antagonist of endothelin (ET) B-receptor (IC₅₀ = 1.2 nM). BQ-788 is a good tool for demonstrating the role of ET-1 and ET(B) receptor subtypes in physiological and/or...

BQCA is a potent M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with selectivity for M1 over M2-M5. The effective range for potentiation of M1 in cells by BQCA is 0.1 to...

BQR-695 is a potent and selective PI4K inhibitor. Displays potency against both human PI4KIIIβ and Plasmodium falciparum asexual blood stages (IC₅₀ values of 90 nM and 71 nM, respectively)...

BQU57 is a GTPase Ral inhibitor. Displays selectivity for Ral relative to the GTPases Ras and RhoA and inhibits tumor xenograft growth to a similar extent to the depletion of Ral using RNA...

K564 | Branched Chain Amino Acid Leu/Ile/Val Colorimetric Assay Kit DataSheet

Branebrutinib is a potent covalent, irreversible inhibitor of Bruton's tyrosine kinase (BTK). BTK is a non-receptor tyrosine kinase. It is a member of the Tec family of kinases and is essential for B...

3364 | BRCA1 Antibody DataSheet

3364BP | BRCA1 Blocking Peptide DataSheetAntibody Target: BRCA1 Accession #: P38398Gene ID: 672Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate buffered...

K4239 | BRCA1 Human Elisa Kit DataSheet

3675 | Anti-BRCA2 Antibody DataSheet

3675BP | BRCA2 Blocking Peptide DataSheetAntibody Target: BRCA2 Accession #: 116508Gene ID: 675Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

BRD-5529 is a selective, cell-permeable CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor (IC50 of 8.6 μM). BRD-5529 directly and selectively binds CARD9, disrupts TRIM62...

BRD-73954 ia a potent and selective HDAC inhibitor with IC₅₀ of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.BRD-73954 ia a potent and selective HDAC inhibitor with IC₅₀ of 36 nM and 120 nM for...

BRD-7552 is an inducer of pancreatic and duodenal homeobox 1 (PDX1), a transcription factor involved in pancreas development and function. BRD-7552 dose-dependently increases PDX1 and insulin gene...

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such...

6281 | BRD2 Antibody DataSheet

6281BP | BRD2 Blocking Peptide DataSheetAntibody Target: BRD2Accession #: Q6MGA9Gene ID: 294276Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such...

6839 | BRD2 polyclonal antibody DataSheet

6282 | BRD3 Antibody DataSheet