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A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as...

Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, EC 1.14.99.1), is an enzyme that is responsible for the formation of important biological mediators called prostanoids,...

K549 | Cyclooxygenase COX Activity Assay Kit Fluorometric DataSheet

K548 | Cyclooxygenase-1 COX-1 Inhibitor Screening Kit Fluorometric DataSheet

Cyclopamine tartrate is a water-soluble derivative of the Hedgehog (Hh) signaling pathway inhibitor Cyclopamine (Cyc) (Cat. No.1578). Displays higher inhibitory activity for Hh signaling-dependent...

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch)...

Cell-permeable. A synthetic derivative of the natural product Cyclopamine (Cat. No. 1578-5) that acts as a specific inhibitor of Smoothened (Smo) and Sonic hedgehog (Shh) intracellular signaling...

PHPT1 is a 125 amino acid enzyme belonging to the Janus protein family. Existing as a monomer in the cytoplasm, PHPT1 is an EDTA-insensitive phosphohistidine phosphatase. Overexpression of PHPT1...

Cyclophosphamide is a cytotoxic agent commonly used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in...

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits...

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin (IC₅₀ = 0.94 nM)Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin (IC₅₀ = 0.94 nM)B2363 | Cyclo（RGDfK）...

Cyproheptadine hydrochloride sesquihydrate is an antagonist of serotonin and histamine. It induces preventive effect against the development of pergolide-induced valvulopathy in a rat model. Also...

3648 | Cyr61 Antibody DataSheet

3648BP | Cyr61 Blocking Peptide DataSheetAntibody Target: Cyr61 Accession #: P18406Gene ID: 16007Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell...

6695 | Cyr61/CCN1 Antibody (Clone 365108) DataSheet

6696 | Cyr61/CCN1 Antibody (Clone 466305) DataSheet

Cysmethynil is a potent, time-dependent inhibitor of Icmt (IC₅₀=

Cystamine is an organic disulfide that inhibits transglutaminase (TGM2) with 44% inhibition observed at a concentration of 2.5 mM. It shows neuroprotective activity in a mouse model of Huntington’s...

A1112 | Cystathionine ?-Synthase Antibody DataSheet

Cystathionine -synthase (CBS; E.C. 4.2.1.22) is a PLP-dependent enzyme which plays a central role in sulfur amino acid metabolism in eukaryotes. CBS catalyzes condensation between serine and...

K998 | Cystathionine α Synthase Activity Assay Kit Fluorometric DataSheet

K695 | Cystathionine α Synthase Inhibitor Screening Kit Fluorometric DataSheet

3486 | Cystatin A Antibody (Clone WR 23/2/3/3) DataSheet

3487 | Cystatin B Antibody (Clone RJMW2E7) DataSheet

E4304 | Cystatin C CST3 Human Elisa Kit DataSheet

E4306 | Cystatin C CST3 Porcine Elisa Kit DataSheet

E4305 | Cystatin C CST3 Rat Elisa Kit DataSheet

Cystatin C is a marker for allograph function in adult transplant patients. Cystatin C regulates extracellular cysteine protease activity, which results from microbial invasion or release of...

K558 | Cysteine Assay Kit Fluorometric DataSheet

Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ values of 11 nM and 18 nM, respectively. Inhibits JAK3 at much higher concentrations (IC₅₀ = 155 nM).Cyt387 is an ATP-competitive...

Cytarabine is a cytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. It is triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor...

K451 | Cytidine Deaminase Activity Assay Kit Fluorometric DataSheet

CDA (Cytidine deaminase) is an enzyme that scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. This protein is one of several deaminases responsible for maintaining...

Cytochalasin D is a cell-permeable fungal toxin that acts as a potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways. It is about 10-fold more...

Cytochlor is a radio-sensitizing pyrimidine nucleoside with potential antineoplastic activity. Cytochlor could be a potentially useful reagent to study chlorine-stressed DNA.Cytochlor is a...

Cytochrome b5a (CYB5A) is a membrane-bound hemoprotein which functions as an electron carrier for several membrane bound oxygenases like cytochrome P450 enzymes. Defects in the CYB5A gene...

Cytochrome c Antibody (Clone 7H8.2C12)

3025 | Cytochrome c Antibody DataSheet

3025BP | Cytochrome c Blocking Peptide DataSheetAntibody Target: Cytochrome c Accession #: NP_036972Gene ID: 25310Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in...

3352BP | Cytochrome c Blocking Peptide DataSheetAntibody Target: Cytochrome c Accession #: Gene ID: Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

3353BP | Cytochrome c Blocking Peptide DataSheetAntibody Target: Cytochrome c Accession #: Gene ID: Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

E4286 | Cytochrome c Human Elisa Kit DataSheet

K257 | Cytochrome c Releasing Apoptosis Assay Kit DataSheet

Cytochrome c is an electron-carrying mitochondrial protein. It is a small heme protein containing a single polypeptide chain and a single heme group, which is covalently attached to the...

K287 | Cytochrome Oxidase Activity Colorimetric Assay Kit DataSheet

K893 | Cytochrome P450 1A2 CYP1A2 Activity Assay Kit Fluorometric DataSheet

K894 | Cytochrome P450 1A2 CYP1A2 Inhibitor Screening Kit Fluorometric DataSheet

K848 | Cytochrome P450 2C19 CYP2C19 Activity Assay Kit Fluorometric DataSheet

K849 | Cytochrome P450 2C19 CYP2C19 Inhibitor Screening Kit Fluorometric DataSheet

K895 | Cytochrome P450 2C9 CYP2C9 Activity Assay Kit Fluorometric DataSheet

K896 | Cytochrome P450 2C9 CYP2C9 Inhibitor Screening Kit Fluorometric DataSheet

K703 | Cytochrome P450 2D6 CYP2D6 Activity Assay Kit Fluorometric DataSheet

K704 | Cytochrome P450 2D6 CYP2D6 Inhibitor Screening Kit Fluorometric DataSheet

Cytochrome P450 2D6 is a member of a family of microsomal enzymes (mono-oxygenases) present in the endoplasmic reticulum membrane, which detoxify xenobiotic compounds. Cytochrome P450 2D6 is the...

K701 | Cytochrome P450 3A4 CYP3A4 Activity Assay Kit Fluorometric DataSheet

K702 | Cytochrome P450 3A4 CYP3A4 Inhibitor Screening Kit Fluorometric DataSheet

3084R | Cytochrome P450 Antibody DataSheet

3084RBP | Cytochrome P450 Blocking Peptide DataSheetAntibody Target: Cytochrome P450 Accession #: NP_000764 Gene ID: 1571Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5...

K700 | Cytochrome P450 Reductase CPR Activity Kit Colorimetric DataSheet

K4186 | Cytokeratin-19 Human Elisa Kit DataSheet

K4150 | Cytomegalovirus CMV IgG Elisa Kit DataSheet

K4151 | Cytomegalovirus CMV IgM Elisa Kit DataSheet

K267 | Cytosol/Particulate Separation Kit DataSheet

Cytostatin is a potent and selective protein phosphatase 2A (PP2A) inhibitor. Cell adhesion inhibitor. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent...

CZ415 is a potent and highly selective mTOR inhibitor.CZ415 is a potent and highly selective mTOR inhibitor.B1726 | CZ415 DataSheetAlternate Name/Synonyms: CZ415; CZ 415; CZ-415;...

CZC-25146 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2) with an IC₅₀ of 4.76 nM. Mutations in LRRK2 are associated with Parkinson's disease. CZC-25146 attenuates LRRK2 G2019S mutant...

CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC₅₀ values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). CZC-54252 attenuates...

CZC-8004 is a pan-specific kinase inhibitor that binds to a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES. It inhibits these kinases at low...

CZC24832 is a selective inhibitor of PI 3-kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay); exhibits limited off-target effects in kinome profiling of 154...

D-Cycloserine is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors. Blocks kainate-induced seizures and displays anticonvulsant effects in rat models. D-Cycloserine...

D-(+)-Biotin is a coenzyme and a B vitamin. May be used to elute proteins from avidin/streptavidin resins.D-(+)-Biotin is a coenzyme and a B vitamin. May be used to elute proteins from...

K213 | D-2-Hydroxyglutarate D2HG Assay Kit Colorimetric DataSheet

D-64131 is a potent tubulin polymerization inhibitor. Cytotoxic and inhibits tumor cell proliferation in vitro (IC₅₀ = 74 nM). Antimitotic agent. Induces G2/M cell cycle arrest.D-64131 is a potent...

K559 | D-Amino Acid Oxidase Activity Assay Kit Fluorometric DataSheet

D-amino-acid oxidase (DAAO) is a peroxisomal enzyme which uses flavin adenine dinucleotide (FAD) as a cofactor and oxidizes D-amino acids to the corresponding imino acids, producing ammonia and...

The D-dimer antigen is a unique marker of fibrin degradation that is formed by the sequential action of 3 enzymes: thrombin, factor XIIIa, and plasmin. Thus D-dimer is not normally found in serum or...

D-erythro-sphingosine is an endogenous component of cell membranes found in a large family of sphingolipids. Inhibits protein kinase C (PKC).D-erythro-sphingosine is an endogenous component of cell...

D-Fructose-1,6-bisphosphate (FBP) is an intermediate in the glycolytic pathway, exerting pharmacological actions on inflammation by inhibiting cytokine production or interfering with adenosine...

K683 | D-Gluconate D-Gluconic Acid Assay Kit Colorimetric DataSheet

Glucose Isomerase catalyzes the reversible isomerization of glucose to fructose and that of xylose to xylulose. The enzyme is widely used in the industrial production of high-fructose corn syrup...

K667 | D-Lactate Colorimetric Assay Kit DataSheet

Synthetic. StayBrite™ D-Luciferin is a luminescent substrate for firefly luciferase (Km ~2 μM). Note: Unlike the Potassium (Cat. No.7903) or Sodium (Cat. No. 7902) salts, Luciferin free acid is not...

D-Luciferin potassium salt is a useful substrate for the enzyme Firefly Luciferase. Upon oxidation by the enzyme luciferase, produces bioluminescence. D-Luciferin can be utilized to assay the...

StayBrite™ D-Luciferin sodium salt is a useful substrate for the enzyme Firefly Luciferase. Upon oxidation by the enzyme luciferase, produces bioluminescence. D-Luciferin can be utilized to assay the...

Luciferin-β-galactoside is a substrate for the commonly used reporter enzyme β-galactosidase. The substrate is cleaved by β-galactosidase to form luciferin and galactose. When used in a model system...

K644 | D-Mannitol Colorimetric Assay Kit DataSheet

D-Serine Dehydratase belongs to the - family of the Pyridoxal phosphate-dependent enzymes and part of the fold-type II family. It binds to one catalytically essential PLP per protein molecule but...

K631 | D-Sorbitol Colorimetric Assay Kit DataSheet

3989 | D-Tag Antibody DataSheet

A reported substrate for members of caspase family proteasesD2R [(L-Asp)2 rhodamine 110] is a reported substrate for members of caspase family proteases1131 | D2R [(L-Asp)2 rhodamine 110]...

3385 | D4-GDI Antibody DataSheet

A cell-permeable, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC₅₀ = 0.3 µM). Also inhibits ALK5 (IC₅₀ = 0.5 µM) and p38ɑMAP kinase (IC₅₀ = 12 µM). Displays selectivity over many other...

Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. Dabigatran selectively and reversibly inhibits human thrombin (Ki = 4.5 nM) as well as...

Daclatasvir is a highly selective inhibitor of HCV NS5A with EC₅₀ of 9-50 pM, for a broad range of HCV replicon genotypes and the JFH-1 genotype 2a infectious virus in cell culture.Daclatasvir is a...

Daidzein is an isoflavone phytoestrogen found in soybean, with antioxidant properties. It increases transactivation of estrogen receptor β-induced transcription. It binds to estrogen receptor β...

Dalbavancin | 2852

Dalbavancin is a second-generation lipoglycopeptide antibiotic that is active against gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), and minimum inhibitory...

Dalcetrapib is a potent CETP modulator. It is a thioester pro-drug that is rapidly hydrolyzed to generate a pharmacologically active thiol. Dalcetrapib modulates cholesteryl ester transfer protein...

Daltroban is an antagonist of thromboxane A2 receptor. Daltroban (20 mg/kg per h i.v.) protects the myocardium from ischaemic injury by preventing ischaemia-induced leukocytosis in cats. Infusion (1...