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MAPKAP kinase2 is a Ser/Thr protein kinase, which is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many...

MAPKAPK3 has a single potential SH3-binding site in the proline-rich N terminus, a putative ATP-binding site, 2 MAP kinase phosphorylation site motifs, and a putative nuclear localization signal. It...

Mapracorat is a selective glucocorticoid receptor agonist (SEGRA) with anti-inflammatory properties. It is in clinical trials for the topical treatment of atopic dermatitis, allergic conjunctivitis...

Maraviroc is a potent and selective C-C chemokine receptor type 5 (CCR5) antagonist drug that is designed to act against HIV by interfering with the interaction between HIV and CCR5. Maraviroc is a...

A broad spectrum matrix metalloprotease (MMP) inhibitor with IC₅₀ values of 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively. It covalently binds to the zinc(II) ion in the...

Marizomib (Salinosporamide A) is a potent, reversible, broad-spectrum, brain-penetrant proteasome inhibitor, that displays antitumor activity in vitro and in vivo.Marizomib (Salinosporamide A) is a...

5823 | MART-1/Melan-A Antibody DataSheet

MART-1 (also known as Melan-A) is a melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Six other melanoma associated antigens recognized by autologous cytotoxic T...

MART-1 (also known as Melan-A) is a melanocyte differentiation antigen or marker recognized by autologous cytotoxic T lymphocytes. It is a membrane protein with one transmembrane peptide. Melan-A is...

Cell-permeable. A protein tyrosine kinase (PTK) inhibitor. targeting KIT that is active, orally bioavailable in vivo, and has low toxicity. Masitinib also potently inhibited recombinant PDGFR and the...

Maspin is a non-inhibitory member of the serpin superfamily, a group of 40-60 kDa serine protease inhibitors. Maspin was discovered in 1994 and has been identified in prostate, thymus, testis,...

Massonianoside B (MA) is a structurally unique natural product inhibitor of DOT1L with an IC50 value of 399 nM. It displays high selectivity for DOT1L over other S-adenosylmethionine (SAM)-dependent...

3658 | Math1 (ATH1/ATOH1) Antibody DataSheet

3658BP | Math1 Blocking Peptide DataSheetAntibody Target: Math1 Accession #: Q92858Gene ID: 474Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

3840 | Matrilin-2 Antibody DataSheet

3840BP | Matrilin-2 Blocking Peptide DataSheetAntibody Target: Matrilin-2 Accession #: O00339Gene ID: 4147Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

Matrine is a biologically active alkaloid isolated from the root of the saphoro plant. It inhibits LPS-induced splenocyte proliferation and release of IL-1 and IL-6 from mouse peritoneal macrophages...

3855 | Matriptase Antibody DataSheet

3855BP | Matriptase Blocking Peptide DataSheetAntibody Target: Matriptase Accession #: EDL83315Gene ID: 114093Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

Matrix Dissociation Buffer (EDTA-based), Sterile-Filtered, Molecular GradeM1090 | Matrix Dissociation Buffer (EDTA-based), Sterile-Filtered, Molecular Grade DataSheetSort Name: Matrix Dissociation...

Mavacoxib is a non-steroidal anti-inflammatory drug (NSAID) that acts as a potent and selective cyclooxygenase-2 (COX-2) inhibitor. Displays anti-inflammatory properties. Useful for treatment of dogs...

Maytansinol is a potent microtubule depolymerizing agent. It inhibits the polymerization of tubulin and depolymerizes the once polymerized tubulin.Maytansinol is a potent microtubule depolymerizing...

3281BP | MBD1 Blocking Peptide DataSheetAntibody Target: MBD1Accession #: Q9UIS9Gene ID: 4152Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

6828 | MBD1 polyclonal antibody DataSheet

3232 | MBD2a Antibody DataSheet

3232BP | MBD2a Blocking Peptide DataSheetAntibody Target: MBD2Accession #: B0BNM2Gene ID: 680172Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

3056 | MBD4 Antibody DataSheet

3056BP | MBD4 Blocking Peptide DataSheetAntibody Target: MBD4Accession #: O95243Gene ID: 8930Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

A1033 | MBP Monoclonal Antibody DataSheet

MBX-8025 is a selective peroxisome proliferator-activated receptor (PPAR) -δ agonist. MBX-8025 may have potential use for the treatment of dyslipidemia, metabolic syndrome, type 2 diabetes, and...

MC-1568 is a selective class II (IIa) histone deacetylase (HDAC II) inhibitor (IC₅₀ = 220 nM). It displays >170-fold selectivity over class I HDACs, including HDAC1.MC-1568 is a selective class II...

3936 | MC4 Receptor Antibody DataSheet

3936BP | MC4 Receptor Blocking Peptide DataSheetAntibody Target: MC4 ReceptorAccession #: NP_058673Gene ID: 17202Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in...

A useful fluorescence resonance energy transfer (FRET) substrate for assaying ECE-1 and ECE-2, ACE1 and ACE2. neprilysin, thermolysin (TLN), MMP-2 and MMP9, thimet oligopeptidase, cathepsin A,...

MCA-YVADAP-K(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2). Upon cleavage by caspase-1 or ACE2, 7-methoxycoumarin-4-acetyl (MCA) is released and its...

3759 | MCAF Antibody DataSheet

3760 | MCAK Antibody DataSheet

MCB-613 is a small-molecule steroid coactivators SRC-1, SRC-2, and SRC-3 that has been used to disrupt cancer cell homeostatic dependence on SRCs. MCB-613 can super-stimulate SRCs’ transcriptional...

MCC950 is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4,...

MCC950 sodium is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1,...

MCF-7 cells, derived from metastatic breast cancer, are the most extensively used cell line for breast cancer research. This MCF 7 nuclear extract is prepared from MCF-7 cells treated with H2O2. The...

5993 | mCherry Antibody DataSheet

mCherry is the second generation monomeric red fluorescent protein that have improved brightness and photostability. The recombinant mCherry is expressed and purified from transformed E. coli using a...

mCherry mAntibody Clone 1 | 5411

K971 | mCherry Quantification Kit DataSheet

3035 | Mcl-1 Antibody DataSheet

3035BP | Mcl-1 Blocking Peptide DataSheetAntibody Target: Mcl-1 Accession #: Q07820Gene ID: 4170Appearance: Colorless liquidConcentration: 0.2 mg/mlFormulation: 50 µg (0.2 mg/ml) in phosphate...

3758 | MCM2 Antibody DataSheet

Monocyte Chemoattractant Protein 1 (MCP-1), also known as CCL2, is thought to be produced by injured or infected tissues. MCP-1 signals through G protein-coupled receptors, CCR2 and CCR4, to recruit...

Macrophage/monocyte chemoattractant protein-1 (MCP-1) plays an important role in the inflammatory response of blood monocytes and tissue microphages. Recombinant rat MCP-1 is a 14.0 kDa protein...

5222 | MCP-1 Antibody DataSheet

Human macrophage/monocyte chemotactic protein-2 (MCP-2) is an 8.9 kDa protein containing 76 amino acid residues. It plays an important role in the inflammatory response of blood monocytes and tissue...

Macrophage/monocyte chemotactic protein-2 (MCP-2) plays an important role in the inflammatory response of blood monocytes, activated T cells, basophils, NK cells, and immature dendritic cells...

Human MCP-3 (Macrophage/Monocyte Chemotactic Protein-3) plays an important role in the inflammatory response of blood monocytes, tissue macrophages, and eosinophils. The recombinant human MCP-3 is a...

Murine MCP-3 (Macrophage/Monocyte Chemotactic Protein-3) plays an important role in the inflammatory response of blood monocytes and T-cells. The recombinant murine MCP-3 is a 8.5 kDa protein...

Monocyte Chemotactic Protein 3 (MCP-3), also called CCL7, is chemokine produced by macrophages and some tumor cell lines. MCP-3 signals through three different G protein-coupled receptors, CCR1,...

Human macrophage/monocyte chemotactic protein-4 (MCP-4) is a member of the chemokine family (C-C) of cytokines. Like eotaxin, MCP-4 is a powerful eosinophil chemoattractant. Additionally, like...

The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T...

Cell-permeable. An irreversible inhibitor of p97 (IC₅₀

5531 | MDC Antibody DataSheet

MDC (CCL22) is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. MDC shows chemotactic activity...

MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts...

Cell-permeable. A selective inhibitor of Dnm1 GTPase (IC₅₀ =1-10 µM). Inhibits mitochondrial outer membrane permeabilization. Inhibits mitochondrial division and apoptosis.Mdivi-1 is a selective...

MDK-7933 is a potent HDAC8 inhibitor with an IC₅₀ of 27.2 nM in cancer cell lines. MDK-7933 displays antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5)...

A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates...

MDL-800 is a potent and selective allosteric activator (EC50 = 10.3 µM) of SIRT6, a member of the SIRT deacetylase family. Does not display any activities toward SIRT1, SIRT3, SIRT4 and HDAC1-11 at...

MDV-3100 (Enzalutamide) is an androgen-receptor (AR) antagonist (IC₅₀ = 36 nM). Prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been...

ME-0328 is a potent and selective PARP-3 inhibitor (IC₅₀ = 0.89 µM). ME-0328 inhibits PARP-1, PARP-2 and other ARDTs (ADP ribosyltransferases) at much higher concentrations (IC₅₀ = 6.3, 10.8 and >30...

E4662 | Measles Rubeola IgG Elisa Kit DataSheet

E4663 | Measles Rubeola IgM Elisa Kit DataSheet

MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting...

MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor and chemoattracts resting...

Meclofenamic acid sodium is a non-steroidal, anti-inflammatory drug that acts as a time-dependent, non-specific competitive inhibitor of COX-1 and -2. Also acts as a highly selective fat mass and...

3199 | MeCP2 Antibody DataSheet

3199BP | MeCP2 Blocking Peptide DataSheetAntibody Target: MeCP2Accession #: P51608Gene ID: 4204Appearance: Colorless liquidConcentration: 0.5 mg/mlFormulation: 50 µg (0.5 mg/ml) in phosphate buffered...

6827 | MeCP2 polyclonal antibody DataSheet

MEDICA 16 is a GPR40 agonist; displays selectivity for FFA1 (GPR40) over GPR120. Exhibits hypolipidemic and antidiabetogenic effects in the rat. Also inhibits ATP citrate lyase.MEDICA 16 is a GPR40...

Medicarpin | B3363Description: Medicarpin is a pterocarpan class of naturally occurring benzopyran furanobenzene compound. In calvarial osteoblasts, medicarpin blocks nuclear factor kappaB (NF-κB)...

Medroxyprogesterone 17-acetate is a synthetic progestogen that blocks fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when...

3683 | MEF2A Antibody DataSheet

A1006 | MEF2C Antibody DataSheet

Mefloquine hydrochloride is a phospholipid-interacting antimalarial drug that is very effective against Plasmodium Falciparum with very few side effects.Mefloquine hydrochloride is a...

Megestrol acetate is a synthetic derivative of the naturally occurring female sex hormone progesterone, with progestogenic, antiestrogenic, and antineoplastic activities. Also acts as an appetite...

Meglumine is a derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. It is used as an excipient for drug formulations and for preparing salts. The...

Meisoindigo is a synthetic derivative of indirubin that acts as a potential agent for acute myeloid leukemia. In the in vitro assay, it can inhibit synthesis of DNA and RNA and the assembly of...

Cell-permeable. A potent, non-ATP competitive inhibitor of MEK1/2 (IC₅₀ = 12 nM) and cellular pERK (IC₅₀ = 11 nM). Selective against a panel of other 220 kinases (displays no activity even at 10 µM)...

3518 | Mek1/2 Antibody DataSheet

E4274 | Melamine Elisa Kit DataSheet

Melatonin is an endogeneous hormone that plays a prominent role in the control of circadian rhythm. Melatonin acts as an agonist at melatonin receptors MT1 and MT2, displays immunomodulatory activity...

Melibiose is a reducing disaccharide formed between galactose and glucose by an α-1,6 linkage. It differs from lactose where the galactose and glucose are bonded through a ß-1, 4 linkage. Immobilized...

K268 | Membrane Protein Extraction Kit DataSheet

Menadione is an inhibitor of indoleamine2,3-dioxygenase (IDO) (IC₅₀ ~ 1 µM). It induces apoptosis via elevation of peroxide radical levels. Cytotoxic in various cell lines.Menadione is an inhibitor...

3797 | Menin Antibody DataSheet

MEP1B, also known as meprin A subunit beta, is a member of the astacin family of zinc endopeptidases 1, 2. It is disulfide-linked, tetrameric metalloendopeptidases in renal brush border membranes. It...

Merestinib is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (Ki) of 2 nM. It shows more anti-proliferative activity in cell lines with MET gene...

Merimepodib (VX-497) is a novel noncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH). Merimepodib is orally bioavailable and inhibits the proliferation of primary human, mouse,...

Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering...

MERS-CoV is a coronavirus which causes the Middles East Respiratory Syndrome (MERS). MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid)...

MERS-CoV is a coronavirus which causes the Middles East Respiratory Syndrome (MERS). MERS-CoV has four structural proteins, known as the S (spike), E (envelope), M (membrane), and N (nucleocapsid)...

MET is a proto-oncogene that encodes a transmembrane growth factor receptor which is a heterodimer of two disulphide linked chains of 50 kd () and 145 kd (). MET is widely expressed in the kidney,...