3,3',5'-Triiodo-L-thyronine | B2017

3,3',5’-Triiodo-L-thyronine (Reverse T3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than 3,3',5-triiodo-L-thyronine. Reverse T3 positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation.

3,3',5’-Triiodo-L-thyronine (Reverse T3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than 3,3',5-triiodo-L-thyronine.

B2017 | 3,3',5'-Triiodo-L-thyronine DataSheet

Alternate Name/Synonyms: O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3; Reverse T3

Appearance: Off-white solid

Formulation: N/A

CAS Number: 5817-39-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₂I₃NO₄

Molecular Weight: 650.97

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A thyroid hormone

MDL Number: MFCD00036864

PubChem CID: 644280

SMILES: C1=CC(=C(C=C1CC(C(=O)O)N)I)OC2=CC(=C(C(=C2)I)O)I

InChi: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1

InChi Key: HZCBWYNLGPIQRK-LBPRGKRZSA-N