3-Deazaneplanocin A hydrochloride | 2444

A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.

3-Deazaneplanocin A hydrochloride is a lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.

2444 | 3-Deazaneplanocin A hydrochloride DataSheet

Alternate Name/Synonyms: DZNep; NSC 617989; 5R-​(4-​amino-​1H-​imidazo[4,​5-​c]pyridin-​1-​yl)-​3-​(hydroxymethyl)-​3-​cyclopentene-​1S,​2R-​diol hydrochloride

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 120964-45-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₂H₁₄N₄O₃. HCl

Molecular Weight: 298.73

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H₂O (~5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A lysine methyltransferase EZH2 (KMT63) inhibitor

MDL Number: MFCD18782644

PubChem CID: 358176

SMILES: C1=CN=C(C2=C1N(C=N2)C3C=C(C(C3O)O)CO)N.Cl

InChi: InChI=1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H

InChi Key: UNSKMHKAFPRFTI-UHFFFAOYSA-N