4μ8C | B2495

4µ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC₅₀ = 60 nM). It blocks substrate access to the active site of IRE1α and inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

4µ8C is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC₅₀ = 60 nM). It blocks substrate access to the active site of IRE1α and inactivates IRE1α-mediated mRNA degradation. Displays no effect on the IRE1α-related endoribonuclease RNase L.

B2495 | 4μ8C DataSheet

Alternate Name/Synonyms: IRE1 Inhibitor III; 7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

Appearance: White to off-white solid

Formulation:

CAS Number: 14003-96-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₈O₄

Molecular Weight: 204.18

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >25 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inositol requiring enzyme 1 α (IRE1α) inhibitor

MDL Number:

PubChem CID: 12934390

SMILES: CC1=CC(=O)OC2=C1C=CC(=C2C=O)O

InChi: InChI=1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3

InChi Key: RTHHSXOVIJWFQP-UHFFFAOYSA-N