4-Aminonaphthalimide | B3134

4-Aminonaphthalimide is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP with an IC₅₀ of 180 nM. It inhibits radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation.

4-Aminonaphthalimide is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP with an IC₅₀ of 180 nM. It inhibits radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation.

B3134 | 4-Aminonaphthalimide DataSheet

Alternate Name/Synonyms: 6-aminobenzo[de]isoquinoline-1,3-dione; 4-Amino-1,8-naphthalimide; 4-Aminonaphthalene-1,8-dicarboximide; 7-Amino-3-hydroxy-1H-benzo[de]isoquinolin-1-one; 4-ANI

Appearance: Orange powder

Formulation:

CAS Number: 1742-95-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₁₂H₈N₂O₂

Molecular Weight: 212.2

Cell-Permeable?: TRUE

Purity: ≥ 95%

Solubilities: ~1 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of PARP

MDL Number: MFCD00006921

PubChem CID: 1720

SMILES: C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)N

InChi: InChI=1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)

InChi Key: SSMIFVHARFVINF-UHFFFAOYSA-N