4-Hydroxyquinazoline | B3148

4-Hydroxyquinazoline is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP with an IC₅₀ of 9.5 μM. 4-hydroxyquinazoline improves the recovery of high-energy phosphates (ATP, creatine phosphate) and accelerates the reutilization of inorganic phosphate formed during ischemia. The quinazoline structure is an important pharmacophore possessing a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities.

4-Hydroxyquinazoline is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP with an IC₅₀ of 9.5 μM. 4-hydroxyquinazoline improves the recovery of high-energy phosphates (ATP, creatine phosphate) and accelerates the reutilization of inorganic phosphate formed during ischemia. The quinazoline structure is an important pharmacophore possessing a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities.

B3148 | 4-Hydroxyquinazoline DataSheet

Alternate Name/Synonyms: 4-HQN; Quinazolin-4-ol

Appearance: White to Light yellow powder

Formulation:

CAS Number: 491-36-1

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₈H₆N₂O

Molecular Weight: 146.15

Cell-Permeable?: TRUE

Purity: ≥ 98%

Solubilities: ~1 mg/ml in DMSO or DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of PARP

MDL Number: MFCD00511302

PubChem CID: 135408753

SMILES: C1=CC=C2C(=C1)C(=O)NC=N2

InChi: InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)

InChi Key: QMNUDYFKZYBWQX-UHFFFAOYSA-N