4E-BP1 polyclonal Antibody | BS90007

4E-BP1 polyclonal Antibody | BS90007 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC FC

Application Range: WB:1:500-1:1,000 ICC:1:500-1:1,000 IHC:1:50-1:200 FC:1:50-1:100

Background: The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: 4E-BP1 polyclonal Antibody detects endogenous levels of 4E-BP1 protein.

Molecular Weight: 12.5 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: 4E-BP1, eIF4E-binding protein 1, PHAS-I, EIF4EBP1, 4E-BP1, 4EBP1, 4EBP1, BP 1, eIF4E binding protein 1, eIF4E-binding protein 1, Eif4ebp1, Eukaryotic translation initiation factor 4E-binding protein 1, PHAS-I, PHASI, Phosphorylated heat- and acid-stable protein regulated by insulin 1,

Immunogen: Recombinant protein.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway: