4EGI-1 | B2901

4EGI-1 is an inhibitor of the interaction of translation initiation factor eIF4G to eIF4E. It inhibits the binding of eIF4G to eIF4E, but not 4E-BP1. The KD for eIF4E binding to 4EGI-1 is 25 μM ± 11 μM. It inhibits proliferation of human cancer cells. It reduces the expression of c-Myc, Cyclin D1, Cyclin E, Bcl-2, bFGF and Survivin in human melanoma cells at a concentration of 50 μM. It strongly inhibits tumor growth in xenograft models of human breast and melanoma cancers.

4EGI-1 is an inhibitor of the interaction of translation initiation factor eIF4G to eIF4E. It inhibits the binding of eIF4G to eIF4E, but not 4E-BP1. The KD for eIF4E binding to 4EGI-1 is 25 μM ± 11 μM. It inhibits proliferation of human cancer cells. It reduces the expression of c-Myc, Cyclin D1, Cyclin E, Bcl-2, bFGF and Survivin in human melanoma cells at a concentration of 50 μM. It strongly inhibits tumor growth in xenograft models of human breast and melanoma cancers.

B2901 | 4EGI-1 DataSheet

Alternate Name/Synonyms: (2E)-2-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]-3-(2-nitrophenyl)propanoic acid; 4tpw; α-[2-[4-(3,4-dichlorophenyl)-2-thiazolyl]hydrazinylidene]-2-nitro-benzenepropanoic acid; AC1NX1IT; AMBZ0333; (E)-2-(2-(4-(3,4-Dichlorophenyl)thiazol-2-yl)hydrazono)-3-(2-nitrophenyl)propanoic acid; eIF4E/eIF4G Interaction Inhibitor

Appearance: A crystalline solid

Formulation:

CAS Number: 315706-13-9

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₈H₁₂Cl₂N₄O₄S

Molecular Weight: 451.28

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~30 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of interaction of eIF4E/eIF4G

MDL Number: MFCD00734038

PubChem CID: 5717952

SMILES: C1=CC=C(C(=C1)CC(=NNC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)C(=O)O)[N+](=O)[O-]

InChi: InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+

InChi Key: KFRKRECSIYXARE-HYARGMPZSA-N