8-Br-cAMP | 1837

A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells. Also recently shown to improve the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells 2-fold.

8-Br-cAMP is a cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

1837 | 8-Br-cAMP DataSheet

Alternate Name/Synonyms: 8- Bromoadenosine- 3', 5'- cyclic monophosphate; cyclic 8- bromoadenosine- 3', 5'- monophosphate; 8- bromoadenosine- 3', 5'-Monophosphate

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 76939-46-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₀BrN₅O₆P. Na

Molecular Weight: 430.08

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: H₂O (~100 mg/ml)

Handling: Protect from moisture and light

Country of Origin: USA

Tag Line: A PKA activator

MDL Number: MFCD00005844

PubChem CID: 23712387

SMILES: C1C2C(C(C(O2)N3C4=C(C(=NC=N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]

InChi: InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3 (21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13, 14);/q;+1/p-1

InChi Key: DMRMZQATXPQOTP-UHFFFAOYSA-M