8-Br-cGMP | 1838

A cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase (PKG), slows or inhibits the intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine. It inhibits thrombin stimulated arachidonic acid release in human platelets.

8-Br-cGMP is a cell-permeable cGMP analog having greater resistance to hydrolysis by phosphodiesterases than cGMP. Activates cGMP-dependent protein kinase (PKG), slows or inhibits the intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine.

1838 | 8-Br-cGMP DataSheet

Alternate Name/Synonyms: 8- Bromoguanosine- 3', 5'- cyclic monophosphate, cyclic 8- bromoguanosine- 3', 5'- monophosphate, 8- bromoguanosine- 3', 5'-monophosphate

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 51116-01-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₀BrN₅O₇P. Na

Molecular Weight: 446.08

Cell-Permeable?: Yes

Purity: ≥95% by TLC

Solubilities: H₂O (~25 mg/ml) or aqueous buffers

Handling: Protect from moisture and light

Country of Origin: USA

Tag Line: A PKG activator

MDL Number: MFCD00070128

PubChem CID: 44134592

SMILES: C1C2C(C(C(O2)N3C4=C(C(=O)N=C(N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]

InChi: InChI=1S/C10H11BrN5O7P.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5- 2(22-8)1-21-24(19,20)23-5;/h2,4-5,8,17H,1H2,(H,19,20)(H3,12,14,15, 18);/q;+1/p-1

InChi Key: ZJRFCXHKYQVNFK-UHFFFAOYSA-M