8-Prenylnarinegin | B3344

8-Prenylnarinegin | B3344

Description: 8-Prenylnaringenin (8-PN) is a non-steroidal phytoestrogen from Hops that mimicks endogenous estrogens via estrogen receptor binding. Inhibits both isoforms of the human estrogen receptor (ER; IC50s = 57nM and 68nM for ERα and ERβ, respectively). Acts as a full agonist of ERα. Anticancer agent with antiangiogenic and antiproliferative properties. Shown to inhibit cell cycle progression, induce apoptosis in MCF-7 cells and induce autophagy in prostate cancer cell lines.

Alternate Name/Synonyms: (-)-(2S)-8-dimethylallylnaringenin (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one Flavaprenin

Appearance: Pale yellow solid

Formulation:

CAS Number: 53846-50-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₀O₅

Molecular Weight: 340.4

CellTRUE

Purity: ≥98% by HPLC

Solubilities: ~5 mg/ml DMSO ~2 mg/ml Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A non-steroidal phytoestrogen

MDL Number:

PubChem CID: 480764

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/480764

SMILES: CC(=CCC1=C2C(=C(C=C1O)O)C(=O)CC(O2)C3=CC=C(C=C3)O)C

InChi: InChI=1S/C20H20O5/c1-11(2)3-8-14-15(22)9-16(23)19-17(24)10-18(25-20(14)19)12-4-6-13(21)7-5-12/h3-7,9,18,21-23H,8,10H2,1-2H3/t18-/m0/s1

InChi Key: LPEPZZAVFJPLNZ-SFHVURJKSA-N

Category: Biochemica