A-317491 | B3367

A-317491 | B3367

Description: A-317491 is a selective non-nucleotide antagonist of P2X3 and P2X2/3 receptor activation. A-317491 potently blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22-92 nM) and is highly selective (IC50 >10 uM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 also blocks native P2X3 and P2X2/3 receptors in rat dorsal root ganglion neurons.

Alternate Name/Synonyms: A317491 5-[(3-phenoxyphenyl)methyl-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid ABT-202

Appearance: Solid

Formulation:

CAS Number: 475205-49-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₃H₂₇NO₈

Molecular Weight: 565.57

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >50 30 mg/ml Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A P2X3 and P2X2/3 receptor antagonist

MDL Number:

PubChem CID: 9829395

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/9829395

SMILES: C1CC(C2=CC=CC=C2C1)N(CC3=CC(=CC=C3)OC4=CC=CC=C4)C(=O)C5=CC(=C(C=C5C(=O)O)C(=O)O)C(=O)O

InChi: InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1

InChi Key: VQGBOYBIENNKMI-LJAQVGFWSA-N

Category: Biochemicals