A-803467 | 2559

A-803467 is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Na(v1.8). Na(v1.8) is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and neuropathic pain in a variety of animal models. IC50's for rat and human Na(v1.8) are 140 nM and 8.0 nM respectively.

A-803467 is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Na(v1.8). Na(v1.8) is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and neuropathic pain in a variety of animal models. IC50's for rat and human Na(v1.8) are 140 nM and 8.0 nM respectively.

2559 | A-803467 DataSheet

Alternate Name/Synonyms: 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 944261-74-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₆ClNO₄

Molecular Weight: 357.8

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~30 mg/ml) or EtOH (~ 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective Na(v1.8) blocker

MDL Number: MFCD10574689

PubChem CID: 16038374

SMILES: ClC1=CC=C(C2=CC=C(C(NC3=CC(OC)=CC(OC)=C3)=O)O2)C=C1

InChi: InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)

InChi Key: VHKBTPQDHDSBSP-UHFFFAOYSA-N