A-803467 | B3214

A-803467 is a selctive a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocks human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥1 μM.

A-803467 is a selctive a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50 = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocks human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥1 μM.

B3214 | A-803467 DataSheet

Alternate Name/Synonyms: A803467,5-4(-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide

Appearance: Off-white solid

Formulation:

CAS Number: 944261-79-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₆ClNO₄

Molecular Weight: 357.79

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective Nav1.8 sodium channel blocker

MDL Number: MFCD10574689

PubChem CID: 16038374

SMILES: COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC

InChi: InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)

InChi Key: VHKBTPQDHDSBSP-UHFFFAOYSA-N