A77 1726 | 1973

Physiologically active metabolite of the immunosuppressive drug leflunomide (Cat. No.1972-10, 50). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner. Also inhibits the activity of COX-2 in vitro and in vivo.

A77 1726 is the physiologically active metabolite of the immunosuppressive drug leflunomide (Cat. No.1972-10, 50). Inhibits the activity of dihydrorotate dehydrogenase and of protein tyrosine kinases. Blocks TNF-mediated NF-κB activation in a dose- and time-dependent manner.

1973 | A77 1726 DataSheet

Alternate Name/Synonyms: N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide

Appearance: White solid

Formulation: N/A

CAS Number: 108605-62-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₉F₃N₂O₂

Molecular Weight: 270.21

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from light and air

Country of Origin: USA

Tag Line: Physiologically active metabolite of the immunosuppressive drug leflunomide

MDL Number: MFCD00910058

PubChem CID: 54684141

SMILES: CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O

InChi: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13, 14)15/h2-5,18H,1H3,(H,17,19)/b10-7-

InChi Key: UTNUDOFZCWSZMS-YFHOEESVSA-N