AAAS Antibody (C-Term) [AMM05524G]

AAAS Antibody (C-Term) [AMM05524G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This AAAS antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between395-425 amino acids from human AAAS.

Cellular Localisation: Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Nucleus envelope. Note=In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate (PubMed:26246606) . The localization to the spindle is microtubule- mediated (PubMed:26246606) .

Molecular Weight: 59574

Clone: Polyclonal

Gene Name: AAAS

Gene ID: 8086

Function: Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474, PubMed:11159947, PubMed:16022285) . Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment (PubMed:26246606) .

Summary: Tissue Location: Widely expressed (PubMed:11159947, PubMed:16022285) . Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung (PubMed:11159947) .

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Aladin, Adracalin, AAAS, ADRACALA