ABC294640 | B1231

ABC294640 is a specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity. This orally available aryl admantane molecule upon administration binds and inhibits SK-2, preventing phosphorylation of the pro-apoptotic amino alcohol spingosine to spingosine-1-phosphate (S1P), the lipid mediator that is important for immunomodulation, this phosphorylation prevention of amino alcohol can induce apoptosis and may inhibit cancer cell proliferation.

ABC294640 is a specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity. This orally available aryl admantane molecule upon administration binds and inhibits SK-2, preventing phosphorylation of the pro-apoptotic amino alcohol spingosine to spingosine-1-phosphate (S1P), the lipid mediator that is important for immunomodulation, this phosphorylation prevention of amino alcohol can induce apoptosis and may inhibit cancer cell proliferation.

B1231 | ABC294640 DataSheet

Alternate Name/Synonyms: 1S,3R,5R,7S)-3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide

Appearance: White to off white solid

Formulation: N/A

CAS Number: 915385-81-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₅ClN₂O

Molecular Weight: 380.91

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(>4 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A specific spingosine kinase-2 (SK-2) inhibitor having antineoplastic activity.

MDL Number: N/A

PubChem CID: 71587865

SMILES: C1C2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl

InChi: InChI=1S/C23H25ClN2O/c24-20-3-1-19(2-4-20)22-10-17-9-18(11-22)13-23(12-17,15-22)21(27)26-14-16-5-7-25-8-6-16/h1-8,17-18H,9-15H2,(H,26,27)/t17-,18?,22?,23?/m0/s1

InChi Key: CAOTVXGYTWCKQE-RZTFFZPQSA-N