ABCA2 Antibody (Center) [APG01396G]

ABCA2 Antibody (Center) [APG01396G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ABCA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1339-1373 amino acids from the Central region of human ABCA2.

Cellular Localisation: Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Forms discrete, punctate intracellular vesicles.

Molecular Weight: 269833

Clone: Polyclonal

Gene Name: ABCA2 (HGNC:32)

Gene ID: 20

Function: Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed:15238223, PubMed:21810484, PubMed:24201375) (Probable) . May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed:24201375) . In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma- secretase processing of APP (PubMed:22086926, PubMed:26510981) . May play a role in myelin formation (By similarity) .

Summary: Tissue Location: [Isoform 3]: Highly expressed in the brain, peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: ATP-binding cassette sub-family A member 2, ATP-binding cassette transporter 2, ATP-binding cassette 2, ABCA2, ABC2, KIAA1062