ABCB7 Antibody (C-term) [APG01418G]

ABCB7 Antibody (C-term) [APG01418G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-746 amino acids from the C-terminal region of human ABCB7.

Cellular Localisation: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P40416}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P40416}

Molecular Weight: 82641

Clone: Polyclonal

Gene Name: ABCB7 (HGNC:48)

Gene ID: 22

Function: Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]- (GS) 4 cluster from the mitochondria to the cytosol in an ATP- dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:33157103, PubMed:17192393, PubMed:10196363) . Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471) . In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity) . May also play a role in hematopoiesis (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ABC transporter 7 protein, ABCB7, ABC7