ABT-263 | 2467

A potent, small molecule Bcl-2 family protein inhibitor (Ki’s of <1 nmol/L for Bcl-2, Bcl-XL and Bcl-w). Displays anticancer properties. Selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

ABT-263 is a potent, small molecule Bcl-2 family protein inhibitor (Ki’s of <1 nmol/L for Bcl-2, Bcl-XL and Bcl-w).

2467 | ABT-263 DataSheet

Alternate Name/Synonyms: (R)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide; Navitoclax

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 923564-51-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₅H₅₅ClF₃N₅O₆S₃

Molecular Weight: 974.61

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (> 50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of antiapoptotic Bcl-2 proteins

MDL Number: N/A

PubChem CID: 24978538

SMILES: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

InChi: InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1

InChi Key: JLYAXFNOILIKPP-KXQOOQHDSA-N