ABT-737 | 2463

A small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w. In vitro, ABT-737 binds Bcl-xL, Bcl-2 and Bcl-w with comparable high affinity, while it has over 1000-fold lower affinities for Bcl-B, Bfl-1 and Mcl-1. Displays wide range of single-agent activity against acute lymphoblastic leukemia (ALL) cell lines and xenografts.

ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w.

2463 | ABT-737 DataSheet

Alternate Name/Synonyms: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 852808-04-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₂H₄₅ClN₆O₅S₂

Molecular Weight: 813.43

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (> 100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective Bcl-2 inhibitor

MDL Number: N/A

PubChem CID: 11228183

SMILES: CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]

InChi: InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1

InChi Key: HPLNQCPCUACXLM-PGUFJCEWSA-N