ABT-888 | 1620

Potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radio-potentiation. Does not show inherent cytotoxicity and shows no single agent activity in tumor models.

ABT-888 is a potent inhibitor of PARP-1 and PARP-2 (potency ≤5 nM in vitro). Does not inhibit other NAD-binding enzymes.

1620 | ABT-888 DataSheet

Alternate Name/Synonyms: 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide . dihydrochloride

Appearance: Coloreless to white crystalline solid

Formulation: N/A

CAS Number: 912445-05-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₆N₄O.2HCl

Molecular Weight: 317.21

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO and H₂O

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A PRP-1 and PARP-2 inhibitor

MDL Number: MFCD16661206

PubChem CID: 11960529

SMILES: CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N

InChi: InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17- 12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1

InChi Key: JNAHVYVRKWKWKQ-CYBMUJFWSA-N