ABT751 | 2836

ABT751 is a potent inhibitor of microtubule polymerization. It binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect.

ABT751 is a potent inhibitor of microtubule polymerization. It binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect.

2836 | ABT751 DataSheet

Alternate Name/Synonyms: N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide

Appearance: Pink solid

Formulation: N/A

CAS Number: 141430-65-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₇N₃O₄S

Molecular Weight: 371.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml) or EtOH (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent microtubule polymerization inhibitor

MDL Number: N/A

PubChem CID: 3035714

SMILES: COC1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC=C2)NC3=CC=C(C=C3)O

InChi: InChI=1S/C18H17N3O4S/c1-25-15-8-10-16(11-9-15)26(23,24)21-17-3-2-12-19-18(17)20-13-4-6-14(22)7-5-13/h2-12,21-22H,1H3,(H,19,20)

InChi Key: URCVCIZFVQDVPM-UHFFFAOYSA-N