ACE-2 Substrate, Fluorogenic | B2726

ACE-2 substrate, Fluorogenic is a useful fluorogenic substrate for angiotensin converting enzyme-2 (ACE-2), a zinc-dependent carboxypeptidase with 42% amino acid sequence identity to ACE1. Unlike Mca-YVADAPK(Dnp)-OH (Cat. No. B2717), this substrate is not cleaved by caspases. This peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. This substrate is useful for inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm.

ACE-2 substrate, Fluorogenic is a useful fluorogenic substrate for angiotensin converting enzyme-2 (ACE-2), a zinc-dependent carboxypeptidase with 42% amino acid sequence identity to ACE1. Unlike Mca-YVADAPK(Dnp)-OH (Cat. No. B2717), this substrate is not cleaved by caspases. This peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. This substrate is useful for inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm.

B2726 | ACE-2 Substrate, Fluorogenic DataSheet

Alternate Name/Synonyms: Mca-Ala-Pro-Lys(Dnp)-OH [Mca=(7-methoxycoumarin-4-yl)acetyl;Dnp=2,4-dinitrophenyl],Mca-APK(Dnp),ACE2 Substrate

Appearance: Yellow solid

Formulation:

CAS Number: N/A

Structure Available?: No

Peptide sequence: Mca-Ala-Pro-Lys(Dnp)-OH

Salt Form: No

Molecular Formula: C₃₂H₃₇N₆O₁₂

Molecular Weight: 697.7

Cell-Permeable?: TRUE

Purity: ≥95% by HPLC

Solubilities: ~2 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A fluorogenic ACE-2 (Angiotensin I-converting enzyme 2) substrate

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