Acebilustat | B3206

Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, that is used as an antiinflammatory drug in development for the treatment of CF and other diseases. Leukotriene A4 hydrolase (LTA4H) catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils.

Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, that is used as an antiinflammatory drug in development for the treatment of CF and other diseases. Leukotriene A4 hydrolase (LTA4H) catalyzes the rate-limiting step in the formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cells including neutrophils.

B3206 | Acebilustat DataSheet

Alternate Name/Synonyms: CTX4430,4-(((1S,4S)-5-(4-(4-(oxazol-2-yl)phenoxy)benzyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)methyl)benzoic acid,EP501,ZK322

Appearance: Crystalline solid

Formulation:

CAS Number: 943764-99-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₂₇N₃O₄

Molecular Weight: 481.55

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >15 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective leukotriene A4 hydrolase inhibitor

MDL Number:

PubChem CID: 68488178

SMILES: O=C(O)C1=CC=C(CN2[C@](C3)([H])CN(CC4=CC=C(OC5=CC=C(C6=NC=CO6)C=C5)C=C4)[C@]3([H])C2)C=C1

InChi: InChI=1S/C29H27N3O4/c33-29(34)23-5-1-20(2-6-23)16-31-18-25-15-24(31)19-32(25)17-21-3-9-26(10-4-21)36-27-11-7-22(8-12-27)28-30-13-14-35-28/h1-14,24-25H,15-19H2,(H,33,34)/t24-,25-/m0/s1

InChi Key: GERJIEKMNDGSCS-DQEYMECFSA-N