Aclacinomycin A hydrochloride | B1905

Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells) the removal of Brg1 from promoters of inflammatory genes elucidating the regulatory role of the proteasome in controlling the duration of the inflammatory process. Induces the differentiation of K562 cells towards the erythroid pathway. Induces apoptosis. Cell permeable.

Aclacinomycin A is a specific inhibitor of the 20S proteasome chymotrypsin-like activity. Inhibition of Brg1 proteasomal degradation by aclacinomycin A reverses (0.25 µM in ILU-18 cells) the removal of Brg1 from promoters of inflammatory genes elucidating the regulatory role of the proteasome in controlling the duration of the inflammatory process. Induces the differentiation of K562 cells towards the erythroid pathway. Induces apoptosis. Cell permeable.

B1905 | Aclacinomycin A hydrochloride DataSheet

Alternate Name/Synonyms: Aclarubicin hydrochloride

Appearance: Orange solid

Formulation: N/A

CAS Number: 75443-99-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₂H₅₃NO₁₅ • HCl

Molecular Weight: 848.3

Cell-Permeable?: Yes

Purity: ≥90% by HPLC

Solubilities: DMSO (~ 30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A specific inhibitor of the 20S proteasome chymotrypsin-like activity.

MDL Number: MFCD00133024

PubChem CID: 153751

SMILES: CCC1(CC(C2=C(C1C(=O)OC)C=C3C(=C2O)C(=O)C4=C(C3=O)C=CC=C4O)OC5CC(C(C(O5)C)OC6CC(C(C(O6)C)OC7CCC(=O)C(O7)C)O)N(C)C)O.Cl

InChi: InChI=1S/C42H53NO15.ClH/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(2)53-29;/h9-11,14,18-20,24,27-31,35,39-40,45-46,49,51H,8,12-13,15-17H2,1-7H3;1H/t18-,19-,20-,24-,27-,28-,29-,30-,31-,35-,39+,40+,42+;/m0./s1

InChi Key: KUSMIBXCRZTVML-PCCPLWKKSA-N