ACPP polyclonal Antibody | BS6510

ACPP polyclonal Antibody | BS6510 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: Human prostatic acid phosphatase (also known as PAcP, PAP, PPAP, ACPP) is a prostate epithelium-specific differentiation antigen. The cellular form of PAcP functions as a neutral protein-tyrosine phosphatase, and is involved in regulating prostate cell growth. Specifically, PAcP catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. PAcP is synthesized under androgen regulation. The stimulated secretion of prostatic acid phosphatase is a hallmark of androgen action on human prostate epithelial cells, implicating PAcP as a useful tool in identifying atrophy of prostatic tissue. Cellular PAcP can down-regulate prostate cancer cell growth, at least partially by dephosphorylating c-ErbB-2/neu. Therefore, decreased cellular PAcP expression in cancer cells may be involved in prostate cancer progression. PAcP is the protein product of the human ACPP gene, which maps to chromosome 3q21-q23.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ACPP polyclonal Antibody detects endogenous levels of ACPP protein.

Molecular Weight: ~ 45 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: 5'-NT; 5'-nucleotidase; Acid phosphatase prostate; ACP 3; ACP3; ACPP; Ecto-5'-nucleotidase; PAP; PPAP; Prostatic acid phosphatase; Prostatic acid phosphotase; Thiamine monophosphatase; TMPase;

Immunogen: Recombinant full length Human ACPP.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: