ACTB-1003 | B2016

ACTB-1003 is a potent kinase inhibitor with IC₅₀s of 6, 2 and 4 nM for FGFR1, VEGFR2 and Tie-2, respectively. Displays anticancer activities.

ACTB-1003 is a potent kinase inhibitor with IC₅₀s of 6, 2 and 4 nM for FGFR1, VEGFR2 and Tie-2, respectively. Displays anticancer activities.

B2016 | ACTB-1003 DataSheet

Alternate Name/Synonyms: 1-(4-(4-amino-6-(methoxymethyl)-7-(morpholinomethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluorophenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 939805-30-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₆F₅N₇O₃

Molecular Weight: 591.53

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent kinase inhibitor

MDL Number: N/A

PubChem CID: 23653175

SMILES: OCC1=C(N2C(=C1C3=CC(=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)F)C(=NC=N2)N)CN5CCOCC5

InChi: InChI=1S/C27H26F5N7O3/c1-41-13-17-22(12-38-6-8-42-9-7-38)39-24(25(33)34-14-35-39)23(17)15-2-5-20(19(29)10-15)36-26(40)37-21-11-16(27(30,31)32)3-4-18(21)28/h2-5,10-11,14H,6-9,12-13H2,1H3,(H2,33,34,35)(H2,36,37,40)

InChi Key: GZPJCJKUZPUFAL-UHFFFAOYSA-N