Active Transmembrane Serine Protease 2 (TMPRSS2), Human Recombinant | P1735

The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the viral spike (S) glycoprotein to the ACE2 receptor and S protein priming by TMPRSS2. TMPRSS2 is also shown to be upregulated by androgen in prostate cancer cells, and downregulated in androgen-independent prostate cancer.

P1735 | Active Transmembrane Serine Protease 2 (TMPRSS2), Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin

Alternates names: Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin

Taglines: A biomarker in prostate cancer and a point of cell entry for SARS-CoV-2

NCBI Gene ID #: 7113

NCBI Gene Symbol:

Gene Source: Human

Accession #: O15393

Recombinant: True

Source: Yeast

Purity by SDS-PAGE: > 85% by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level:

Activity (Specifications/test method): Recombinant Human TMPRSS2 enzyme activity is measured by its ability to cleave fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC), Km is 21.93 uM.

Biological activity:

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: 44.8 kDa (calculated)

Concentration:

Appearance: Liquid protein

Physical form description: Liquid

Reconstitution Instructions:

Amino acid sequence: Partial sequence of TMPRSS2 (amino acids 106 to 492) with N-terminal 6xHis Tag

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans