Activin A, rat recombinant | 4726

Activin A is a member of the TGFbeta family of proteins produced by many cell types throughout development. Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two beta A chains and is not biologically active until the N terminal propeptide is cleaved from each. Rat Activin A has 100% amino acid sequence identity to human, mouse, porcine, bovine and feline proteins. Recombinant rat Activin A is a non-glycosylated homodimer, containing two 117 amino acid chains, with a total molecular weight of 26.2 kDa.

4726 | Activin A, rat recombinant DataSheet

Biomolecule/Target :

Synonyms: Inhibin beta-1, FRP, FSH-releasing protein

Alternates names: Inhibin beta-1, FRP, FSH-releasing protein

Taglines: A protein complex enhancing FSH biosynthesis and secretion

NCBI Gene ID #: 3624

NCBI Gene Symbol: INHBA

Gene Source: Rat

Accession #: P08476

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGE: ≥95%

Assay: SDS-PAGE

Purity: ≥95%

Assay #2: HPLC

Endotoxin Level: <0.1 EU/ug purified protein

Activity (Specifications/test method): N/A

Biological activity: The activity is determined by the ability to induce cytoxicity of MPC-11 cells and is typically less than 2 ng/mL.

Results: < 2 ng/mL

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 26.2 kDa

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Recombinant rat Activin A is lyophilized with 0.02% TFA.

Reconstitution Instructions: Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water, which can then be further diluted to other aqueous solutions.

Amino acid sequence: MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans