ACTN1 Polyclonal Antibody | E-AB-70225

ACTN1 Polyclonal Antibody | E-AB-70225 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: actinin 1 smooth muscle, Actinin alpha 1, actinin, alpha 1, ACTN 1, Actn1, ACTN1, Alpha Actinin 1, Alpha actinin cytoskeletal isoform, Alpha-actinin cytoskeletal isoform, Alpha-actinin-1, BDPLT15, F actin cross linking protein, F-actin cross-linking protein, FLJ40884, FLJ54432, Non muscle alpha actinin 1, Non-muscle alpha-actinin-1

Application: WB

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Developmental Biology, Signal Transduction, Stem Cells

Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Concentration: 0.66 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein corresponding to Mouseα-actinin1

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: WB 1:1000-1:3000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 102-107 kDa

Molecular Weight(Observed): 110 kDa