ADA Antibody (C-term) [APG01544G]

ADA Antibody (C-term) [APG01544G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This ADA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 287-314 amino acids from the C-terminal region of human ADA.

Cellular Localisation: Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P03958}. Cytoplasm. Lysosome. Note=Colocalized with DPP4 at the cell surface.

Molecular Weight: 40764

Clone: Monoclonal

Gene Name: ADA

Gene ID: 100

Function: Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine (PubMed:8452534, PubMed:16670267) . Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412) . Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392) . Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity) . Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412) . Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172) . Stimulates plasminogen activation (PubMed:15016824) . Plays a role in male fertility (PubMed:21919946, PubMed:26166670) . Plays a protective role in early postimplantation embryonic development (By similarity) .

Summary: Tissue Location: Found in all tissues, occurs in large amounts in T- lymphocytes (PubMed:20959412) . Expressed at the time of weaning in gastrointestinal tissues.

Form: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:500~1000

Synonyms: Adenosine deaminase, Adenosine aminohydrolase, ADA, ADA1