ADAMTS2 polyclonal Antibody | BS60092

ADAMTS2 polyclonal Antibody | BS60092 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: ADAMTS (a disintegrin and metalloproteinase domain with Thrombospondin type-1 modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS genes are primarily expressed in fetal tissues, including the lung, kidney and liver. ADAMTS-2 cleaves the propeptides of Collagen Type I and II, but not Collagen Type III, prior to fibril assembly. It may also play a role in development aside from collagen biosynthesis. ADAMTS-2 is secreted and associated with the extracellular matrix, with the highest levels in skin, bone, tendon and aorta. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type VIIC (EDS VIIC), a recessively inherited connective-tissue disorder characterized clinically by severe skin fragility and joint hypermobility.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ADAMTS2 polyclonal Antibody detects endogenous levels of ADAMTS2 protein.

Molecular Weight: ~ 135 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: A disintegrin and metalloproteinase with thrombospondin motifs 2; ADAM-TS 2; ADAM-TS2; ADAMTS-2; Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI; PCINP; PCPNI

Immunogen: A synthetic peptide corresponding to residues in Human ADAMTS2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: