ADAMTS4 Antibody [AMM22274G]

ADAMTS4 Antibody [AMM22274G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This ADAMTS4 antibody is generated from a mouse immunized with a recombinant protein from the human region of human ADAMTS4.

Cellular Localisation: Secreted, extracellular space, extracellular matrix

Molecular Weight: 90197

Clone: Monoclonal

Gene Name: ADAMTS4

Gene ID: 9507

Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Summary: Tissue Location: Expressed in brain, lung and heart (PubMed:23897278) . Expressed at very low level in placenta and skeletal muscles (PubMed:23897278) . Isoform 2: Detected in osteoarthritic synovium (PubMed:16723216, PubMed:23897278)

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:8000

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 4, ADAM-TS 4, ADAM-TS4, ADAMTS-4, 3.4.24.82, ADMP-1, Aggrecanase-1, ADAMTS4, KIAA0688