Adapalene | B2733

Adapalene is a synthetic Retinoic acid analog that acts as a RARβ and RARγ agonist (AC₅₀ values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).

Adapalene is a synthetic Retinoic acid analog that acts as a RARβ and RARγ agonist (AC₅₀ values are 2.2, 9.3, 22 and > 1000 nM for RARβ, RARγ, RARα and RXRα receptors respectively). Inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).

B2733 | Adapalene DataSheet

Alternate Name/Synonyms: 6-(4-methoxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid,CD271

Appearance: White to light yellow solid

Formulation:

CAS Number: 106685-40-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₈O₃

Molecular Weight: 412.53

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: ~5 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A synthetic retinoid acid analog

MDL Number: MFCD03106112

PubChem CID: 172088913

SMILES: COC1=C(C23CC(C4)CC(CC4C3)C2)C=C(C=C1)C(C=C5)=CC6=C5C=C(C(O)=O)C=C6

InChi: InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)/t17-,18+,19?,28?

InChi Key: LZCDAPDGXCYOEH-XCGNNYAZSA-N