Adaptaquin | B2706

Adaptaquin is a brain-permeable hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) inhibitor. It stabilizes HIF-1α protein and induces expression of the HIF-1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. Adaptaquin protects against cell death induced by glutathione depletion in rat primary cortical neurons (IC50 = 0.25 μM) and reduces glutamate-induced cell death in HT-22 cells. Displays neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Also acts as an antioxidant.

Adaptaquin is a brain-permeable hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) inhibitor. It stabilizes HIF-1α protein and induces expression of the HIF-1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. Adaptaquin protects against cell death induced by glutathione depletion in rat primary cortical neurons (IC50 = 0.25 μM) and reduces glutamate-induced cell death in HT-22 cells. Displays neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes. Also acts as an antioxidant.

B2706 | Adaptaquin DataSheet

Alternate Name/Synonyms: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol

Appearance: Off-white solid

Formulation:

CAS Number: 385786-48-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₆ClN₃O₂

Molecular Weight: 377.82

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: HIF-prolyl hydroxylase-2 (PHD2) inhibitor

MDL Number:

PubChem CID: 3740671

SMILES: C1=CC2=C(C(=C(C=C2)C(C3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)O)O)N=C1

InChi: InChI=1S/C21H16ClN3O2/c22-15-8-5-14(6-9-15)18(25-21-17(26)4-2-12-24-21)16-10-7-13-3-1-11-23-19(13)20(16)27/h1-12,18,26-27H,(H,24,25)

InChi Key: KKYHNYRUBSYTCZ-UHFFFAOYSA-N