AdipoRon | 2565

A potent and selective adiponectin receptor agonist (Kd = 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively). Displays similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reverses insulin resistance and glucose intolerance in mice on a high-fat diet. It ameliorates diabetes in a genetically obese mouse model and prolongs the shortened lifespan of db/db mice on a high-fat diet.

AdipoRon is a potent and selective adiponectin receptor agonist (Kd=1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively). Displays similar effects to adiponectin in muscle and liver such as activation of PPARα and AMPK signaling pathways. It also reverses insulin resistance and glucose intolerance in mice on a high-fat diet.

2565 | AdipoRon DataSheet

Alternate Name/Synonyms: 2-(4-Benzylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide

Appearance: White solid

Formulation: N/A

CAS Number: 924416-43-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₈N₂O₃

Molecular Weight: 428.54

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO (~40 mg/ml) or EtOH (~ 20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An adiponectin receptor agonist

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(C1=CC=C(OCC(NC2CCN(CC3=CC=CC=C3)CC2)=O)C=C1)C4=CC=CC=C4

InChi: InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)

InChi Key: SHHUPGSHGSNPDB-UHFFFAOYSA-N