ADRBK1 Antibody (C-term) [APR14068G]

ADRBK1 Antibody (C-term) [APR14068G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ADRBK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 633-660 amino acids from the C-terminal region of human ADRBK1.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}

Molecular Weight: 79574

Clone: Polyclonal

Gene Name: GRK2 (HGNC:289)

Gene ID: 156

Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (PubMed:19715378) . Key regulator of LPAR1 signaling (PubMed:19306925) . Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (PubMed:19306925) . Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner (PubMed:19306925) . Positively regulates ciliary smoothened (SMO) -dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity) . Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927) .

Summary: Tissue Location: Expressed in peripheral blood leukocytes.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Beta-adrenergic receptor kinase 1, Beta-ARK-1, G-protein coupled receptor kinase 2, ADRBK1, BARK, BARK1, GRK2