ADW-742 | B2197

ADW-742 is an ATP-competitive inhibitor of IGF1R (IC₅₀ in the range of 0.1-0.2 μM) with potential anticancer activity. It synergistically enhances the sensitivity of SCLC (small cell lung cancer) to etoposide and carboplatin.

ADW-742 is an ATP-competitive inhibitor of IGF1R (IC₅₀ in the range of 0.1-0.2 μM) with potential anticancer activity. It synergistically enhances the sensitivity of SCLC (small cell lung cancer) to etoposide and carboplatin.

B2197 | ADW-742 DataSheet

Alternate Name/Synonyms: 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine; GSK552602A

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 475488-23-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₁N₅O

Molecular Weight: 453.58

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An ATP-competitive inhibitor of IGF1R

MDL Number: N/A

PubChem CID: 9825149

SMILES: C1CCN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6

InChi: InChI=1S/C28H31N5O/c29-27-26-25(22-9-6-10-24(15-22)34-18-20-7-2-1-3-8-20)17-33(28(26)31-19-30-27)23-13-21(14-23)16-32-11-4-5-12-32/h1-3,6-10,15,17,19,21,23H,4-5,11-14,16,18H2,(H2,29,30,31)

InChi Key: LSFLAQVDISHMNB-UHFFFAOYSA-N