ADX-47273 | 9562

ADX-47273 is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC₅₀ = 0.17 μm, with no effect on other mGluR subtypes. ADX-47273 elevates extracellular signal-regulated kinase and cAMP-responsive element-binding protein phosphorylation in hippocampus and prefrontal cortex.

ADX-47273 is a potent and selective mGluR5 receptor PAM (positive allosteric modulator), EC₅₀ = 0.17 μm, with no effect on other mGluR subtypes. ADX-47273 elevates extracellular signal-regulated kinase and cAMP-responsive element-binding protein phosphorylation in hippocampus and prefrontal cortex.

9562 | ADX-47273 DataSheet

Alternate Name/Synonyms: (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 851881-60-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₇F₂N₃O₂

Molecular Weight: 369.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective mGluR5 receptor PAM (positive allosteric modulator)

MDL Number: N/A

PubChem CID: 11383075

SMILES: C1CC(CN(C1)C(=O)C2=CC=C(C=C2)F)C3=NC(=NO3)C4=CC=C(C=C4)F

InChi: InChI=1S/C20H17F2N3O2/c21-16-7-3-13(4-8-16)18-23-19(27-24-18)15-2-1-11-25(12-15)20(26)14-5-9-17(22)10-6-14/h3-10,15H,1-2,11-12H2/t15-/m0/s1

InChi Key: VXQCCZHCFBHTTD-HNNXBMFYSA-N