AF/LE Purified Anti-Human CD20 Monoclonal Antibody | DL22239F

AF/LE Purified Anti-Human CD20 Monoclonal Antibody | DL22239F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: Bp35, Leukocyte surface antigen Leu-16, MS4A1, B-lymphocyte surface antigen B1

Reactivity: Human

Application: Depletion, FCM, IHC, IP

Background: CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn) . It exists in a complex with MHC class I and II, CD53, CD81, and CD82.

Concentration: 0.2 mg/mL

Conjugation: None (Purified antibody, Azide Free/Low endotoxin)

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.

Clone: 2H7

Isotype: Mouse IgG2b, κ