AF/LE Purified Anti-Human CD28 Monoclonal Antibody | DL22135F

AF/LE Purified Anti-Human CD28 Monoclonal Antibody | DL22135F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: PAS2, MNS, HGpMiX, GYPA, GPSAT

Reactivity: Human

Application: Activ, FCM, IHC, IP

Background: CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.

Concentration: 0.2 mg/mL

Conjugation: None (Purified antibody, Azide Free/Low endotoxin)

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/μg) as Determined by LAL gel clotting assay.

Clone: CD28.2

Isotype: Mouse IgG1, κ